CD31: beyond a marker for endothelial cells
نویسندگان
چکیده
منابع مشابه
Irradiation induces upregulation of CD31 in human endothelial cells.
Radiation-induced vascular injury is believed to be a major factor contributing to parenchymal atrophy, fibrosis and necrosis in normal tissue after radiotherapy. In this study irradiation of human umbilical vein endothelial cells (HUVECs) significantly increased adherence of U-937 cells in a time-dependent manner. Given the potential multifunctional role of CD31 in the vasculature we have exam...
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The transmembrane ubiquitin ligase K5/MIR2 of Kaposi sarcoma herpesvirus (KSHV) mediates internalization and lysosomal degradation of glycoproteins involved in antigen presentation and co-stimulation. In endothelial cells (ECs), K5 additionally reduced expression of CD31/platelet-endothelial cell adhesion molecule (PECAM), an adhesion molecule regulating cell-cell interactions of ECs, platelets...
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4,230,558 A 10/1980 Fulwyler 4,318,846 A 3, 1982 Khanna et al. 4,375.407 A 3, 1983 Kronick 4,452,773. A 6/1984 Molday 4,650,750 A 3, 1987 Giese 4,795,698 A 1, 1989 Owen et al. 4,811,218 A 3/1989 Hunkapiller et al. 4,943,533 A 7, 1990 Mendelsohn et al. 4,997,928 A 3/1991 Hobbs, Jr. 5,096,815 A 3, 1992 Ladner et al. 5, 183,884 A 2f1993 Kraus et al. 5,194,596 A * 3/1993 Tischer et al. ...............
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Background: Vascular endothelial growth factor-A (VEGF-A), an endothelial cell-specific mitogen produced by various cell types, plays important roles in cell differentiation and proliferation. In this study we investigated the effect of recombinant VEGF-A on differentiation of mesenchymal stem cells (MSCs) to endothelial cells (ECs). Methods: VEGF-A was expressed in E. coli BL21 (DE3) and BL21...
متن کاملPECAM-1 (CD31) regulates a hydrogen peroxide–activated nonselective cation channel in endothelial cells
Hydrogen peroxide (H2O2) released by neutrophils is an important mediator of endothelial cell (EC) injury and vascular inflammation via its effect on EC-free Ca2+, [Ca2+]i. Although the underlying mechanisms are not well understood, platelet endothelial cell adhesion molecule (PECAM)-1/CD-31 is a critical modulator of neutrophil-EC transmigration. PECAM-1 is also known to regulate EC calcium si...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2012
ISSN: 0008-6363
DOI: 10.1093/cvr/cvs108